JACC: Advances (2025) — the world's largest analysis of wearable-measured sleep architecture and development of atrial fibrillation. 52,952 participants. A result leaving no room for interpretation.
Bedroom of an Engadine chalet just before dawn: cold bluish light from the window, pale linen sheets, a smart ring and watch resting on the nightstand; no faces.
The concrete numbers
Subjects who developed AF showed at baseline shorter deep sleep (0.82 vs 0.98 hours, p\<0.001) and shorter REM (1.14 vs 1.31 hours, p\<0.001).
Macro detail of a wearable ring and a smartwatch recording sleep phases in low light; night-blue tones, soft reflections; no faces.
A measurable, reproducible, statistically robust difference across 50,000+ people.
Independent predictors — what this means
Reduction in deep sleep and REM, and increase in light sleep are independent predictors of AF risk.
Luminous chart of REM and deep-sleep phases projected on the dark wall of a premium clinical room; soft light, order; no faces.
'Independent' means the finding holds even after controlling for age, sex, BMI, hypertension, diabetes and other risk factors.
The implication for Klinik Sankt Moritz
Chalet window at dawn framing the snowy Engadine peaks seen from an unmade bed; cold natural light, stillness; no faces.
With 52,952 patients as support, wearable sleep monitoring is evidence-based medicine of the highest quality. Klinik Sankt Moritz integrates it as a primary cardiological risk marker in the Digital Twin.
What your Digital Twin can do today
Silent corridor of an Alpine clinic at dawn, warm materials (wood and stone) and soft light; a mood of clinical calm; no faces.
If your wearable measures sleep phases, you are already collecting this research's data. The Digital Twin analyses it clinically, building your personalised cardiovascular risk profile updated every 24 hours.
Bedroom of an Engadine chalet just before dawn: cold bluish light from the window, pale linen sheets, a smart ring and watch resting on the nightstand; no faces.
Yazdanpanah et al. — JACC: Advances (2025/2026) — https://pmc.ncbi.nlm.nih.gov/articles/PMC12859236/ · pmc.ncbi.nlm.nih.gov
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